Features of structural organization of the telencephalon human fetus of 7–8 weeks fetal development


  • V.S. Shkolnikov
  • P.O. Stelmashchuk
Keywords: telencephalon, morphometric parameters, fetal period, radial glia.

Abstract

An anatomical and histological, immunohistochemical and morphometric study of the cerebral hemispheres of 12 human fetuses gestational period — 7–8 weeks. White and gray matter of the cerebral hemispheres is the characteristic arrangement of cells in 5 layers. The total thickness is uneven, depending on the proportion of the brain The expression of Ki-67 is defined as a thin strip throughout the ventricular zone, which is an indication that the ventricular zone is primary in shaping the future neural cells and radial glial cells. Radial glial fibers start from the basement membrane ventricular zone, subventricular permeate zone in the radial direction and reach the boundary area. Synaptophysin expression as a marker of postsynaptic membranes was completely absent throughout the ventricular zone of the brain hemispheres, while a strong expression was observed in the intermediate zone and cortical.

References

1. Bielska, L. M. (2015). Stovburovi klityny pukhlyn holovnoho mozku: fenotypichna kharakterystyka ta metody napravlenoho terapevtychnoho vplyvu. Klitynna ta orhanna transplantolohiia, 3(2), 170–176. [in Ukrainian].

2. Matveeva, E. P., & Ryzhavskij, B. Ya. (2011). Morfometricheskie osobennosti subventrikulyarnoj zony mozga novorozhdennyh krys, razlichayushihsya velichinoj massy mozga i stepenyu razvitiya neokorteksa. Dalnevostochnyj medicinskij zhurnal, 4, 93. [in Russian].

3. Obuhov, D. K., Obuhova, E. V. & Pushina, E. V. (2012). Sovremennye predstavleniya ob evolyucii konechnogo mozga pozvonochnyh zhivotnyh Mezhdunarodnyj zhurnal eksperimentalnogo obrazovaniya, 6, 19–21. [in Russian].

4. Shkolnikov, V. S., Tykholaz, V. O., Stelmashchuk P. O. & Datsyshyn, P. T. (2015). Patent Ukrainy 98355, MPK A61V 5/107. Kyiv: Derzhavne patentne vidomstvo Ukrainy. [in Ukrainian].

5. Tsymbaliuk, V. I., & Medvediev, V. V., (2011). Neirohenni stovburovi klityny u nevrolohii ta neirokhirurhii. Zhurn. NAMN Ukrainy, 17(1), 76–80. [in Ukrainian].

6. Chaikovskyi, Yu. B., Dieltsova, O. I. & Herashchenko, S. B. (2011) Stovburovi klityny holovnoho mozku v postnatalnomu periodi. Svit medytsyny ta biolohii, 4, 148–153. [in Ukrainian].

7. Boitor-Borza, D., Kovacs, T. & Stamatian, F. (2015). Transvaginal three-dimensional sonographic assessment of the embryonic brain: a pilot study. Clujul Med., 88 (2), 152–8.

8. Del Bigio, M. R. (2011). Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage. Brain, 134 (5), 1344–61.

9. Müller, F. & O'Rahilly, R. (1990). The human brain at stages 21-23, with particular reference to the cerebral cortical plate and to the development of the cerebellum. Anat Embryol (Berl), 182 (4), 375–400.

10. Müller, F. & O'Rahilly, R. (1990). The human brain at stages 18-20, including the choroid plexuses and the amygdaloid and septal nuclei. Anat Embryol (Berl), 182 (3), 285–306.

11. Ostrem, B., Lui, J., & Hertz, C. (2014). Control of outer radial glial stem cell mitosis in the human brain. Cell Rep., 8(3), 656–664.

12. Sarnat, H. B., & Born, D. E., (1999). Synaptophysin immunocytochemistry with thermal intensification: a marker of terminal axonal maturation in the human fetal nervous system. Brain Dev., 21 (1), 41–50.

13. Sarnat, H. B., Flores-Sarnat, L., & Trevenen, C. L. (2010). Synaptophysin immunoreactivity in the human hippocampus and neocortex from 6 to 41 weeks of gestation. J. Neuropathol. Exp. Neurol., 69 (3), 234–45.

14. Vinci, L. (2016). Immunohistochemical Markers of Neural Progenitor Cells in the Early Embryonic Human Cerebral Cortex. Eur. J. Histochem., 60 (1), 2563.
Published
2017-09-29
How to Cite
Shkolnikov, V., & Stelmashchuk, P. (2017). Features of structural organization of the telencephalon human fetus of 7–8 weeks fetal development. Reports of Vinnytsia National Medical University, 21(2), 400-405. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/13