Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by lactoprotein with sorbitol

  • R.M. Matkivska
Keywords: skin burn injury, infusion therapy, Lactoprotein with sorbitol, structural changes, aggregated lymphoid nodules.

Abstract

With the help of light and electron microscopy it was determined that the general signs of structural changes in aggregated lymphoid nodules of ileum (Peyer’s patch) in rats with the experimental thermal skin injury are necrosis and apoptosis of functionally different cells which occur against the background of significant changes of haemo and lymphatic microvasculature. It is determined that membranoplastic effect of lactoprotein with sorbitol has distinct organ specific traits which present in “exclusion” of range of hemocapillaries from hemomicrocirculatory system due to appearance of circular membrane structure acting as ansa and contributing to vascular lumen closure. It is proved that most damaged hemocapillaries are more transformed and are “excluded” first. It leads to changes in hemomicrocirculation that induce changes in lymphatic microcirculation and relevant changes of selective recirculation of lymphocytes that are not structurally damaged. Considering unsystematic cells aggregation of various immunocytes which are in different functional status and at different stages of responsive and destructive transformation (“overfill” phenomenon) in the lumen of juxta nodules lymph capillaries results in their migration to lymph nodule must be negative as for adequate performance of the immune function.

Downloads

Download data is not yet available.

References

1. Hunas, I. V., Dzevulska, I. V., Cherkasov, E. V. & Kovalchuk, O. I. (2015). Vykorystannia membranoplastychnykh vlastyvostei laktoproteinu-S dlia ponovlennia struktur vnutrishnikh orhaniv pry opikovii khvorobi. Naukovyi visnyk Uzhhorodskoho universytetu, 1 (51), 17–22. [in Ukrainian].
2. Hunas, I. V., Dzevulska, I. V., Cherkasov, E. V. & Kovalchuk, O. I. (2015). Membranoplastychnyi efekt dii laktoproteinu-S na strukturu orhaniv neiroimunoendokrynnoi systemy za umov infuziinoi terapii opikovoi khvoroby. Khirurhiia Ukrainy, 3, 36–43. [in Ukrainian].
3. Gunas, I. V., Cherkasov, V. G., Kovalchuk, A. I., Dzevulskaya, I. V., Cherkasov, E. V., Malikov, A. V., … Matkivskaya, R. M. (2015). Rol endogennoj intoksikacii v morfogeneze izmenenij vo vnutrennih organah pri infuzionnoj terapii ozhogovoj bolezni. Biomedical and biosocial anthropology, 24, 30–36. [in Russian].
4. Kovalchuk, A. I., Dzevulskaya, I. V., Malikov, A. V., Titarenko, V. N., Cherkasov, E. V., Lahtadyr, T. V. & Matkivskaya, R. M. (2014). Vliyanie kombinirovannyh giperosmolyarnyh rastvorov na nanoprocessy v stenke krovenosnyh kapillyarov i v intersticialnom matrikse vnutrennih organov pri ozhogovoj bolezni. Ukrayinskij naukovo-medichnij zhurnal, 2 (81), 5–11. [in Russian].
5. Cherkasov, V. G., Kovalchuk, A. I., Dzevulskaya, I. V., Cherkasov, E. V., Malikov, A. V., Titarenko, V. N., … Matkivskaya, R. M. (2014). Strukturnye mehanizmy citoprotekcii vo vnutrennih organah pri infuzionnoj terapii ozhogovoj bolezni. Biomedical and biosocial anthropology, 23, 6–12. [in Russian].
6. Cherkasov, V. G., Dzevulskaya, I. V., Kovalchuk, A. I., Malikov, A. V., Lahtadyr, T. V., Titarenko, V. N. & Matkivskaya, R. M. (2015). Ultrastrukturnye izmeneniya endoteliya krovenosnyh kapillyarov vnutrennih organov pri lechenii ozhogovoj bolezni putem infuzii kombinirovannyh giperosmolyarnyh rastvorov. Visnik morfologiyi, 21(1), 96–102. [in Russian].
7. Abdulahi, A., Amini-Nik, S. & Jeschke, M.G. (2014). Animal models in burn research. Cell Mol. Life Sci., 71 (17), 3241–3255.
8. Castro-Sanchez, P. & Martin-Villa, G.M. (2013). Gut immune system and oral tolerance. Br J. Nutr., 109 (2), 3–11.
9. Fan J., Xie, Y., Li, X., Guo, G., Meng, O., Xin, Y., Li, T., Feng, W. & Ma, L. (2009). The influence of Peyer’s patch apoptosis on intestinal mucosal immunity in burned mice. Burns., 35 (5), 687–694. doi:S0305-4179(08)00350-1
10. Kovalchuk, O., Cherkasov, E., Dzevulska, I., Kaminsky, R., Korsak, A. & Sokurenko, L. (2017). Dynamics of morphological changes of rats’ adenohypophysis in burn disease. Georgian Med News, 270, 104–108.
Published
2017-09-29
How to Cite
Matkivska, R. (2017). Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by lactoprotein with sorbitol. Reports of Vinnytsia National Medical University, 21(2), 385-392. Retrieved from https://reports-vnmedical.com.ua/index.php/journal/article/view/10